Adult Cardiology Clinical Trials

Study Title Description
 QuikClot 300 QuikClot® Radial® Pad Versus TR Band® After Transradial Artery Access (TRA)  To evaluate the efficacy and safety of the QuikClot® Radial® pad on hemostasis after TRA, compared to the standard of care TR Band®, with the goal to hopefully develop a safe and efficacious technique to achieve more rapid patent hemostasis after TRA, and improve patient care by optimizing radial hemostasis management.
 DEFINE-GPS  Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR CoRegistration using commercially available Philips pressure guidewires and the SyncVision co-registration system, employing an adaptive design study for interim sample size re-estimation.
TAVR UNLOAD Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD) The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate AS as compared with OHFT.
 DAPA ACT HFTIMI 68 Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure Thrombolysis in Myocardial Infarction 68 (DAPA ACT HFTIMI 68) A Multicenter, Randomized, Double-Blind, Parallel Group, Placebo-Controlled Trial to Evaluate the Effect of In-Hospital Initiation of Dapagliflozin on Clinical Outcomes in Patients with Heart Failure with Reduced Ejection Fraction Who Have Been Stabilized During Hospitalization for Acute Heart Failure
 Abbott LESS-VT FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT Study This clinical investigation is intended to demonstrate the safety and effectiveness of ventricular ablation therapy using the FlexAbility Sensor Enabled Ablation Catheter in patients with drug-refractory monomorphic ventricular tachycardia in whom ventricular tachycardia recurs despite antiarrhythmic drug therapy or when antiarrhythmic drugs are not tolerated or desired.
 RELIEVE-HF  Reducing Lung CongestIon Symptoms in Advanced Heart Failure  The objective of the RELIEVE-HF study is to provide reasonable assurance of safety and effectiveness of the VWave Interatrial Shunt System by improving meaningful clinical outcomes in patients with New York Heart Association (NYHA) functional class III or ambulatory class IV heart failure (HF), irrespective of left ventricular ejection fraction, who at baseline are treated with guideline-directed drug and device therapies.
 AIM HIGHer  Assessment of Implantable CCM in the Heart Failure Group With Higher Ejection Fraction  The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤60%.